Hi Daniel,
Sorry I missed this post earlier. Can you confirm for me that the comptuers have different sets applied. Meaning when you go to comptuers and select a computer the dropd down lists lists something other than default which you have created.
Also then verify for me that when you go to that profiles settings the settings you select are saved upon your return to the custom profile value.
Which projects are you attached to and have you made any changes to preferences on those sites between changing the settings on GridRepublic?